An international team of scientists have used tiny diamonds, or nanodiamonds, to measure heat transfer inside living cells, potentially leading to new diagnostic tools and therapies for cancer.
Associate Professor Taras Plakhotnik, from The University of Queensland’s School of Mathematics and Physics, in collaboration with researchers from Osaka University and the National University of Singapore, facilitated the measurements with an unconventional approach.
Dr Plakhotnik detailed that the team coated the nanodiamonds with a heat-releasing polymer and when irradiated with light from a laser, such particles can act both as heaters and thermometers, allowing the thermal conductivity of the interior of the cell to be calculated.
“This is a significant breakthrough since, even though the cell is the fundamental unit of all living organisms, some of its physical properties have remained difficult to study,” he said.
“A cell’s thermal conductivity – the rate that heat can flow through an object if one side is hot and another is cold – has remained mysterious.”
“But now we’re able to determine the thermal conductivity inside living cells with a spatial resolution of about 200 nanometres, which is incredibly accurate.”
Dr Plakhotnik explained that this level of resolution allowed for measurements in different locations inside cells.
“Closing this gap in our knowledge is important for applications such as developing thermal therapies targeting cancer cells and bacteria, and for answering fundamental questions about cell operation,” he said.
And the team’s invention has already revealed some fascinating results.
“We found that the rate of heat diffusion in cells, as measured in our experiments, was several times slower than in pure water, for example,” Dr Plakhotnik said.
Osaka University’s Associate Professor Madoka Suzuki added the applications of the new technology were exhilarating, and could provide hope for a number of medical conditions.
“This research shows that our particles are not toxic and can be used in living cells,” Dr Suzuki commented.
“In addition to improving heat-based treatments for cancer, we think potential applications for this work will result in a better understanding of metabolic disorders, such as obesity.”
“This tool may also be used for basic cell research, for example, to monitor biochemical reactions in real-time.”
“A variety of effective treatments are potentially ahead, so we’re looking forward to seeing this technology in action,” Dr Suzuki said.
The research has been published in Science Advances (DOI: 10.1126/sciadv.abd7888).
